A hybrid discrete-continuum model of immune responses to SARS-CoV-2 infection in the lung alveolar region, with a focus on interferon induced innate responseArticle Published on 2022-12-212022-11-15 Journal: Journal of theoretical biology [Category] COVID19(2023년), SARS, 변종, 치료제, [키워드] adaptive alveolar alveolar cells antibodies antibody antibody concentration baseline Cell cell death Cellular automaton COVID-19 develop diffusion domain Efficacy Future Gas exchange healthy human lung Immune cell immune protection immune response Immunity infected cell Infection initial Innate innate immune Innate immunity innate response Interaction interferon interferons lung alveolar maintain manuscript mechanism Model multiple mechanism outcome Pneumonia produced profiles progression Result RNA copy SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variant simulations. Spread Strains submitted switching T cells the SARS-CoV-2 virus two-dimensional type I Viral load virion virions [DOI] 10.1016/j.jtbi.2022.111293 PMC 바로가기
Production of single-cycle infectious SARS-CoV-2 through a trans-complemented repliconArticle Published on 2022-12-012022-11-16 Journal: Journal of medical virology [Category] COVID19(2023년), SARS, 치료기술, [키워드] acute respiratory syndrome approach BAC Cell cells clone coated Coronavirus-2 COVID-19 culture supernatant did not produce elicit expression generate IFN immune response infected cell Infection Infectious virus Live attenuated vaccine memory N protein nucleocapsid omicron overexpression plaques platform Production progeny provide Replication replicon rescued resulting RNA robust S protein SARS-CoV-2 single-cycle infectious virus. Strains transient expression transmission electron microscopy type I interferon Vaccine Viral RNA virion virus [DOI] 10.1002/jmv.28057 PMC 바로가기
Endoplasmic reticulum secretory pathway: Potential target against SARS-CoV-2Article Published on 2022-10-152022-11-15 Journal: Virus research [Category] COVID19(2023년), SARS, 신약개발, 치료제, [키워드] accelerate acute respiratory syndrome approach approved benefit caused cell membrane Clinical use coronavirus Coronavirus disease 2019 COVID-19 death demonstrated dependent on drug effort Endoplasmic reticulum ERS pathway Extensive feasibility globe inhibitor New overcome pathway pharmacological Potential Protein protein translation regulatory agencies Replication resulting SARS-CoV-2 SARS-COV-2 infection secretory pathway shown suppress targeting the SARS-CoV-2 therapeutic option unfolded protein response Unfolded protein response. virion [DOI] 10.1016/j.virusres.2022.198897 PMC 바로가기
Evaluation of the relative potential for contact and doffing transmission of SARS-CoV-2 by a range of personal protective equipment materialsArticle Published on 2022-10-052022-11-15 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 치료제, [키워드] acute respiratory syndrome Adsorption aerosol analysed antiviral potency caused Community Contact coronavirus coronavirus disease correlation doffing Efficacy equipment evaluated global public health healthcare Infection Ion m/z negative correlation no correlation Personal protective equipment Physicochemical properties Polymer positive PPE Protective reduction in Regression model SARS-CoV-2 transmission the SARS-CoV-2 titre Transmission transmission of SARS-CoV-2 virion virus while [DOI] 10.1038/s41598-022-20952-8 PMC 바로가기
Computational exploration of the dual role of the phytochemical fortunellin: Antiviral activities against SARS-CoV-2 and immunomodulatory abilities against the hostArticle Published on 2022-10-012022-11-15 Journal: Computers in biology and medicine [Category] COVID19(2023년), SARS, 유전자 메커니즘, 치료제, [키워드] activity acute respiratory syndrome analyses Analysis Antiviral antiviral activity apoptosis pathway approach bind binding site Colon coronavirus disease Coronavirus-2 COVID-19 COVID-19 patients effective endoribonuclease enrichment enrichment analysis evaluate Fortunellin generate Genetic growth Host identify immunomodulation immunomodulatory immunomodulatory capability Infection inherent inhibiting Invasion liver lung cell majority mechanism MM-GBSA analysis molecular molecular docking molecular dynamics Molecular dynamics simulation Multi-target mutability network network pharmacology NHBE Ontology Organoid pancreatic pathway per day pro-inflammatory cytokine protective immunity protein-protein interaction SARS-CoV-2 SARS-CoV-2. Support target target proteins targets the SARS-CoV-2 therapeutic tissue damage tissues treating COVID-19 viral replication virion virus [DOI] 10.1016/j.compbiomed.2022.106049 PMC 바로가기
Optimization of Anti-SARS-CoV-2 Treatments Based on Curcumin, Used Alone or Employed as a PhotosensitizerArticle Published on 2022-09-272022-11-15 Journal: Viruses [Category] SARS, 치료제, [키워드] anti-inflammatory properties Antiviral approach Cell culture cells Concentration COVID-19 Curcuma Curcumin dose effective immunomodulatory in vitro In vitro infection inhibited optimization photodynamic therapy photodynamic therapy. photosensitizer prophylactic treatment reduction reported RNase SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 replication suggested therapy Treatment Vero E6 VERO E6 cells virion virus virus inactivation [DOI] 10.3390/v14102132 PMC 바로가기
A Study on the Nature of SARS-CoV-2 Using the Shell Disorder Models: Reproducibility, Evolution, Spread, and AttenuationArticle Published on 2022-09-232022-11-16 Journal: Biomolecules [Category] SARS, 변종, [키워드] applied attenuation bat-CoV contagiousness coronavirus Coronaviruses correlated CoV COVID COVID-19 demonstrated disorder enzyme greater Hard immune system implication intrinsic Long COVID lung membrane protein Nature nucleocapsid protein nucleoprotein observation omicron pangolin Particle PID predicted PROTECT Replication Saliva SARS-CoV-2 shell supported tissues transmissions variant Viral load virion virulence virulence. virus [DOI] 10.3390/biom12101353 PMC 바로가기
SARS-CoV-2 requires acidic pH to infect cellsArticle Published on 2022-09-202022-11-15 Journal: Proceedings of the National Academy of Sciences of [Category] SARS, 치료기술, 치료제, [키워드] 3D imaging Acidic acidic pH acute respiratory syndrome cathepsin Cell cell entry cleavage coronavirus detect endosomal furin Genome infect cell Infection Infection route live-cell imaging membrane membrane fusion nasal occurred penetration producing SARS-CoV-2 target cells TMPRSS2 TMPRSS2-expressing cell virion virus entry Virus entry. [DOI] 10.1073/pnas.2209514119 PMC 바로가기
Model of the SARS-CoV-2 Virus for Development of a DNA-Modified, Surface-Enhanced Raman Spectroscopy Sensor with a Novel Hybrid Plasmonic Platform in Sandwich ModeArticle Published on 2022-09-192022-11-15 Journal: Biosensors [Category] SARS, 치료기술, 치료제, [키워드] acute respiratory syndrome amplification amplifying Antigen approach aptasensor Combination complexes component Compound coronavirus coronavirus detect Developed development DNA domain high stability hybrid Infection Interaction investigated mode Model novel Particle platform Protein provided RBD S-protein Sandwich SARS-CoV-2 SARS-CoV-2 virus scattering sensitivity sensor Spectroscopy Structure Surface-enhanced Raman scattering (SERS). the S protein the SARS-CoV-2 the SARS-CoV-2 virus virion virus viruses Wuhan [DOI] 10.3390/bios12090768 PMC 바로가기
Surface Inactivation of Highly Mutated SARS-CoV-2 Variants of Concern: Alpha, Delta, and OmicronArticle Published on 2022-09-122022-11-16 Journal: Biomacromolecules [Category] SARS, 변종, [키워드] adaptive Alpha Antiviral Complete Degradation Delta dominant effective Evolution Face mask glycosylated inactivation independent induce Infection ingestion Mask mice mutations non-toxic omicron Omicron variant pandemic physical barrier Polymer reduction SARS-CoV-2 SARS-CoV-2 transmission Spike protein Spread surface Transmission Vaccine variant variants variants of concern viral genome viral membrane virion virulence virus VoC VOCs waning immunity [DOI] 10.1021/acs.biomac.2c00801 PMC 바로가기